Iron Metabolism in Human Health and Disease

  • CategoryOther
  • TypeE-Books
  • LanguageEnglish
  • Total size91.3 MB
  • Uploaded Byfreecoursewb
  • Downloads43
  • Last checkedJul. 08th '25
  • Date uploadedJul. 07th '25
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Iron Metabolism in Human Health and Disease



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English | 2025 | ISBN-10: 3031920325 | 428 pages| Epub PDF (True) | 91 MB

This book provides a state-of-the-art overview on the role of bioiron in health and disease. Iron is an essential constituent of simple and complex organisms and has played a critical role in the origin of life. Cells utilize iron for energy metabolism, oxygen transport, and several biochemical reactions due to its flexible coordination chemistry and its unique ability to serve both as electron donor and acceptor. The term “bioiron” was coined to emphasize the importance of iron in biology and medicine.
Even though iron is an abundant metal, its bioavailability is limiting. This often leads to iron-deficient states, which manifest in anemia and other co-morbidities. In fact, iron deficiency is the most common medical condition worldwide. On the other hand, excess iron is potentially toxic due to its redox reactivity. Iron toxicity is illustrated in pathologies of iron overload disorders, such as hereditary hemochromatosis or iron-loading anemias. Deregulation of iron metabolism is also observed in prevalent metabolic, cardiovascular, or neurological disorders.

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